Urolithin A (UA) is a gut microbiota-derived metabolite produced from ellagitannins and ellagic acid found in pomegranate, berries, and nuts. It is a member of the urolithin family and among the best studied postbiotic metabolites with proposed mitochondrial health benefits.
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Andreux PA, et al. The Therapeutic Relevance of Urolithins, Intestinal Metabolites of Ellagitannin-Rich Food: A Systematic Review of In Vivo Studies. Nutrients. 2022. https://mdpi-res.com/dAttachment/nutrients/nutrients-14-03494/article_deploy/nutrients-14-03494.pdf ↩︎ ↩︎ ↩︎ ↩︎
Singh A, D’Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8821002/ ↩︎
Iglesias A, et al. Gut Bacteria Involved in Ellagic Acid Metabolism To Yield Human Urolithin Metabotypes Revealed. BMC Microbiology. 2024. https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-024-03626-5 ↩︎ ↩︎
Urolithin A: Diet-derived UA production by Enterocloster species. Nature Communications 2022/2025. https://www.nature.com/articles/s41430-021-00950-1 ↩︎