细胞衰老是一种永久性的细胞周期停滞状态,伴随着细胞形态、代谢和分泌谱的深刻变化。衰老最初作为一种肿瘤抑制机制演化而来,但在机体衰老过程中,随着衰老细胞的积累并分泌破坏周围组织、促进与年龄相关病理的炎症因子,它变得具有破坏性。
区分衰老细胞最显著的特征是它们的炎症分泌谱:
这些药物可选择性地消除衰老细胞:
这些方法在不杀死细胞的情况下调节 SASP:
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属于 衰老标志 系列的一部分