营养感应失调是指监测和响应营养物质可用性的细胞通路发生与年龄相关的功能障碍。这些保守的信号网络（包括 insulin/IGF-1、mTOR、AMPK 和 sirtuins）协调着生长、代谢和应激反应。它们在衰老过程中的失调会导致代谢功能障碍、抗逆性降低以及细胞衰退加速。
这些通路在不同物种中高度保守：
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Kenyon, C. J. (2010). "The genetics of ageing." Nature, 464(7288), 504-512. PubMed
Saxton, R. A., & Sabatini, D. M. (2017). "mTOR signaling in growth, metabolism, and disease." Cell, 168(6), 960-976. PubMed
Hardie, D. G., et al. (2012). "AMPK: a nutrient and energy sensor that maintains energy homeostasis." Nature Reviews Molecular Cell Biology, 13(4), 251-262. PubMed
Imai, S., & Guarente, L. (2014). "NAD+ and sirtuins in aging and disease." Trends in Cell Biology, 24(8), 464-471. PubMed
Fontana, L., et al. (2010). "Extending healthy life span--from yeast to humans." Science, 328(5976), 321-326. PubMed
属于 衰老标志 系列的一部分