线粒体功能障碍是指随着衰老而发生的线粒体功能、结构和质量控制的进行性衰退。作为负责产生能量的细胞“动力工厂”，线粒体的退化会显著影响细胞代谢，导致氧化应激，并在衰老过程及与年龄相关的疾病中发挥核心作用。
线粒体是双层膜细胞器，其功能包括：
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属于 衰老标志 系列的一部分