干细胞耗竭是指在衰老过程中，成体干细胞再生能力的进行性下降。这一特征包括干细胞数量、功能和分化潜能的丧失，导致组织稳态受损、修复能力下降，并最终促成与年龄相关的器官功能衰退和疾病易感性增加。
López-Otín, C., et al. (2023). "Hallmarks of aging: An expanding universe." Cell, 186(2), 243-278. PubMed
Oh, J., et al. (2014). "Stem cell aging: mechanisms, regulators and therapeutic opportunities." Nature Medicine, 20(8), 870-880. PubMed
Schultz, M. B., & Sinclair, D. A. (2016). "When stem cells grow old: phenotypes and mechanisms of stem cell aging." Development, 143(1), 3-14. PubMed
Geiger, H., et al. (2013). "The ageing haematopoietic stem cell compartment." Nature Reviews Immunology, 13(5), 376-389. PubMed
Kuhn, H. G., et al. (2018). "Adult hippocampal neurogenesis: a coming-of-age story." Journal of Neuroscience, 38(49), 10401-10410. PubMed
Conboy, I. M., et al. (2005). "Rejuvenation of aged progenitor cells by exposure to a young systemic environment." Nature, 433(7027), 760-764. PubMed
属于 衰老标志 系列