Thymosin Alpha-1 (Tα1) 是一种由胸腺产生的天然多肽的合成版本。它是一种强效的免疫调节剂,能够增强机体针对感染的免疫反应,并有助于在自身免疫情况下调节免疫系统。
要点
Thymosin Alpha-1 主要通过 Toll样受体 (TLRs)(特别是 TLR9)发挥作用,刺激细胞因子的产生并增强各种免疫细胞的活性。它促进 T淋巴细胞 (T-lymphocytes) 的成熟,并恢复 Th1/Th2 免疫反应的平衡 [1:1][4]。
Goldstein, A. L., et al. (2015). Thymosins: Chemistry, Biology, and Clinical Applications. Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.12851 ↩︎ ↩︎
Matteucci, C., et al. (2017). Thymosin alpha 1 and Cancer: Action on Immune System and Directly on Cancer Cells. Expert Opinion on Biological Therapy. https://doi.org/10.1080/14712598.2017.1360211 ↩︎
King, R., & Tuthill, C. (2016). Thymosin Alpha 1: A Comprehensive Review of its Safety and Efficacy. Journal of Peptide Science. https://doi.org/10.1002/psc.2891 ↩︎
Serafino, A., et al. (2014). Thymosin α1: A Protective Peptide in the Immune System. Current Pharmaceutical Design. https://doi.org/10.2174/13816128113199990425 ↩︎