姜黄素（Curcumin）是提取自姜黄（Curcuma longa）的主要生物活性化合物，是现代医学中研究最广泛的天然化合物之一 [1]。姜黄素在阿育吠陀医学（Ayurvedic medicine）中拥有超过3000年的传统使用历史，并有超过12000篇科学文献发表。它已成为一种强效的抗炎、抗氧化和抗衰老化合物，在延长寿命方面具有巨大潜力 [2]。
姜黄素（Curcumin）是一种多酚类化合物，其独特的结构使其具备多种生物活性：
姜黄（Turmeric）在阿育吠陀医学中已有 3000 多年的使用历史，主要用于：
姜黄素表现出对环氧合酶-2（COX-2）的选择性抑制作用，与现代 NSAIDs 类似，但副作用更少 [3]：
姜黄素最重要的抗炎机制涉及对核因子 kappa B（NF-κB）的抑制 [6]：
姜黄素通过多种机制表现出强大的抗氧化活性 [10]：
| 结果 | 证据质量 | 临床效果 | 主要发现 | 引用 |
|---|---|---|---|---|
| 骨关节炎疼痛与功能 | 中等 | 积极 | 在缓解疼痛和改善身体功能方面与 NSAIDs（布洛芬）相当，且胃肠道副作用较少。 | [3:1][4:1] |
| 血脂异常（血脂谱） | 中等 | 积极 | 显著降低总胆固醇、LDL 和甘油三酯，适度增加 HDL。 | [11:1][14:1] |
| 全身性炎症 | 中等 | 积极 | 可靠地降低循环炎症标志物，包括 CRP、IL-6 和 TNF-α。 | [5:1][13:1] |
| 血糖控制（2型糖尿病） | 低 | 积极 | 降低空腹血糖和 HbA1c；改善糖尿病人群的胰岛素敏感性（HOMA-IR）。 | [10:1][19] |
| 重度抑郁症 | 低 | 积极 | 在初步试验中疗效与氟西汀相当；减轻抑郁和焦虑症状。 | [9:1] |
| 阿尔茨海默病 / 认知衰退 | 极低 | 人体数据不足 | 尽管有强有力的体外/动物机制数据，但在改善记忆的人体试验中结果不一或数据稀少。 | [8:1] |
| 长寿 / 寿命 | 极低 | 人体数据不足 | 没有直接的人体证据表明能延长人类寿命或延缓原发性衰老。 | [15:1] |
多项随机对照试验表明了姜黄素的疗效：
研究 1：姜黄素与布洛芬的对比（2014年） [4:2]
研究 2：Meriva®（姜黄素-磷脂酰胆碱复合物） [2:1]
姜黄素的生物利用度较差，原因在于：
姜黄素代表了传统智慧与现代科学的非凡融合，为增进健康和延长寿命提供了巨大的潜力。凭借大量支持其抗炎、抗氧化和抗衰老特性的临床证据，姜黄素已成为促进健康衰老最具前景的天然化合物之一。
最大化姜黄素益处的关键在于通过改进配方和合理的剂量策略来解决其生物利用度方面的挑战。随着研究不断揭示新的机制和应用，姜黄素有望在基于证据的延寿和健康衰老方法中发挥日益重要的作用。
Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007). Curcumin: the Indian solid gold. Advances in Experimental Medicine and Biology, 595, 1-75. https://pubmed.ncbi.nlm.nih.gov/17569205/ ↩︎
Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., ... & Appendino, G. (2010). Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Alternative Medicine Review, 15(4), 337-344. https://pubmed.ncbi.nlm.nih.gov/21194249/ ↩︎ ↩︎ ↩︎
Kuptniratsaikul, V., Thanakhumtorn, S., Chinswangwatanakul, P., Wattanamongkonsil, L., & Thamlikitkul, V. (2009). Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. Journal of Alternative and Complementary Medicine, 15(8), 891-897. https://pubmed.ncbi.nlm.nih.gov/19678780/ ↩︎ ↩︎
Aggarwal, B. B., & Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. The International Journal of Biochemistry & Cell Biology, 41(1), 40-59. https://pubmed.ncbi.nlm.nih.gov/18662800/ ↩︎ ↩︎ ↩︎ ↩︎
Panahi, Y., Hosseini, M. S., Khalili, N., Naimi, E., Majeed, M., & Sahebkar, A. (2015). Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis. Clinical Nutrition, 34(6), 1101-1108. https://pubmed.ncbi.nlm.nih.gov/25618800/ ↩︎ ↩︎ ↩︎ ↩︎
Sahebkar, A., Serban, C., Ursoniu, S., Wong, N. D., Muntner, P., Graham, I. M., ... & Lipid and Blood Pressure Meta‐analysis Collaboration Group. (2015). Effect of curcuminoids on oxidative stress: a systematic review and meta‐analysis of randomized controlled trials. Journal of Functional Foods, 18, 898-909. https://www.semanticscholar.org/paper/8fff0c202cc3d86ee544def7c2fa2867d2422623 ↩︎
DiSilvestro, R. A., Joseph, E., Zhao, S., & Bomser, J. (2012). Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal, 11(1), 79. https://pubmed.ncbi.nlm.nih.gov/23013352/ ↩︎
Baum, L., Lam, C. W., Cheung, S. K., Kwok, T., Lui, V., Tsoh, J., ... & Mok, V. (2008). Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. Journal of Clinical Psychopharmacology, 28(1), 110-113. https://pubmed.ncbi.nlm.nih.gov/18204357/ ↩︎ ↩︎
Sanmukhani, J., Satodia, V., Trivedi, J., Patel, T., Tiwari, D., Panchal, B., ... & Tripathi, C. B. (2014). Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytotherapy Research, 28(4), 579-585. https://pubmed.ncbi.nlm.nih.gov/23832433/ ↩︎ ↩︎
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., & Jirawatnotai, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 35(11), 2121-2127. https://pubmed.ncbi.nlm.nih.gov/22773702/ ↩︎ ↩︎ ↩︎
Yang, Y. S., Su, Y. F., Yang, H. W., Lee, Y. H., Chou, J. I., & Ueng, K. C. (2014). Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytotherapy Research, 28(12), 1770-1777. https://pubmed.ncbi.nlm.nih.gov/25131839/ ↩︎ ↩︎
Akazawa, N., Choi, Y., Miyaki, A., Tanabe, Y., Sugawara, J., Ajisaka, R., & Maeda, S. (2012). Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutrition Research, 32(10), 795-799. https://pubmed.ncbi.nlm.nih.gov/23146777/ ↩︎
Ganjali, S., Sahebkar, A., Mahdipour, E., Jamialahmadi, K., Torabi, S., Akhlaghi, S., ... & Parizadeh, S. M. (2014). Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. The Scientific World Journal, 2014. https://pubmed.ncbi.nlm.nih.gov/24678280/ ↩︎ ↩︎
Panahi, Y., Khalili, N., Sahebi, E., Namazi, S., Reiner, Ž., Majeed, M., & Sahebkar, A. (2017). Curcuminoids modify lipid profile in type 2 diabetes mellitus: a randomized controlled trial. Complementary Therapies in Medicine, 33, 1-5. https://pubmed.ncbi.nlm.nih.gov/28735818/ ↩︎ ↩︎
Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: a review of its effects on human health. Foods, 6(10), 92. https://www.semanticscholar.org/paper/97e3124549ffc46250f9a775ad19347e1481d700 ↩︎ ↩︎ ↩︎ ↩︎
Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F., & Walters, M. A. (2017). The essential medicinal chemistry of curcumin: miniperspective. Journal of Medicinal Chemistry, 60(5), 1620-1637. https://pubmed.ncbi.nlm.nih.gov/28074653/ ↩︎ ↩︎
Prasad, S., Tyagi, A. K., & Aggarwal, B. B. (2014). Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Research and Treatment, 46(1), 2-18. https://pubmed.ncbi.nlm.nih.gov/24520218/ ↩︎ ↩︎
Jurenka, J. S. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative Medicine Review, 14(2), 141-153. https://www.semanticscholar.org/paper/87b3dad038a419944c152eca821b22f7cd1f0da4 ↩︎ ↩︎ ↩︎ ↩︎
Pulido-Moran, M., Moreno-Fernandez, J., Ramirez-Tortosa, C., & Ramirez-Tortosa, M. (2016). Curcumin and health. Molecules, 21(3), 264. https://pubmed.ncbi.nlm.nih.gov/26927041/ ↩︎ ↩︎
Menon, V. P., & Sudheer, A. R. (2007). Antioxidant and anti-inflammatory properties of curcumin. Advances in Experimental Medicine and Biology, 595, 105-125. https://pubmed.ncbi.nlm.nih.gov/17569207/ ↩︎ ↩︎
Goel, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2008). Curcumin as "Curecumin": from kitchen to clinic. Biochemical Pharmacology, 75(4), 787-809. https://pubmed.ncbi.nlm.nih.gov/17900536/ ↩︎ ↩︎
Shehzad, A., Rehman, G., & Lee, Y. S. (2013). Curcumin in inflammatory diseases. Biofactors, 39(1), 69-77. https://pubmed.ncbi.nlm.nih.gov/23281076/ ↩︎
Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2013). Therapeutic roles of curcumin: lessons learned from clinical trials. The AAPS Journal, 15(1), 195-218. https://pubmed.ncbi.nlm.nih.gov/23143785/ ↩︎ ↩︎
Kocaadam, B., & Şanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition, 57(13), 2889-2895. https://pubmed.ncbi.nlm.nih.gov/26528921/ ↩︎ ↩︎
Tomeh, M. A., Hadianamrei, R., & Zhao, X. (2019). A review of curcumin and its derivatives as anticancer agents. International Journal of Molecular Sciences, 20(5), 1033. https://www.semanticscholar.org/paper/9b13640cc91eccc43dbb7276dd7ae358af36b79f ↩︎ ↩︎