🚨 EXPERIMENTAL TREATMENT WARNING
These interventions are NOT standard of care. Evidence is preliminary, risks are poorly characterized, and long-term effects are unknown. Participation should be considered experimental self-experimentation, not medical treatment. Consult qualified healthcare providers and consider clinical trial participation before independent use.
¶ Core Interventions
The "gold standard" of pharmacological lifespan extension in animal models. mTOR inhibition mechanism.
First drug to be tested specifically for aging (TAME trial). AMPK activator and blood sugar regulator.
Restoring cellular energy metabolism. Comprehensive review of NMN, NR, and IV therapies.
Targeting "zombie cells" (senescent cells) that accumulate with age and drive systemic inflammation.
Partial reprogramming (Yamanaka factors) to reset cellular age without losing identity. The theoretical future.
Signaling molecules like Epitalon, MOTS-c, and Humanin that modulate specific aging pathways.
¶ Risk Assessment Framework
| Risk Level | Category | Characteristics | Examples |
|---|---|---|---|
| Lower Risk | Repurposed Drugs | Known safety profiles, off-label use, generic availability, physician-prescribable. | Metformin, Low-dose Rapamycin |
| Moderate Risk | Supplements & Peptides | Unregulated quality, limited human data, unknown interactions, counterfeit risks. | NMN, NAD+ IV, Research Peptides |
| High Risk | Experimental Procedures | No human safety data, irreversible effects, unregulated providers, legal gray areas. | Gene therapy, Unproven stem cell clinics |
¶ Deep Dives & Analysis
A critical, evidence-based review of emerging frontier interventions. Separation of hype vs reality.
The debate between anabolic benefits and cancer/aging risks. Understanding the trade-offs.
¶ Frequently Asked Questions
Should I try frontier treatments now or wait?
Consider waiting if: You're under 40, in good health, risk-averse, or uncomfortable with uncertainty.
Consider exploring if: You're over 50, have age-related decline, understand the risks, and can afford potential losses.
Best approach: Optimize lifestyle first, then consider lower-risk options (metformin, rapamycin) with physician supervision.
How do I find legitimate clinical trials?
Check reliable databases like ClinicalTrials.gov, EU Clinical Trials Register, or WHO International Clinical Trials Registry.
Red flags: Trials charging participants, lack of IRB approval, no published protocol, pressure to enroll quickly.
What's the difference between research chemicals and supplements?
Research chemicals are sold "not for human consumption," have no quality control, and carry high contamination risks.
Supplements are regulated as food (GMP), must list ingredients, and are legally safer though quality varies.
Pharmaceuticals have strict FDA approval and quality control.
Can I combine multiple frontier treatments?
Generally not recommended. Interactions are unknown. Start ONE intervention at a time, run for 3-6 months, and evaluate before adding anything else.
What's the regulatory status?
- Rapamycin/Metformin: Legal off-label use (FDA-approved for other conditions).
- NMN: FDA investigation status (2022) created uncertainty; technically not a supplement.
- Peptides: Mostly "research use only" gray market.
- Gene Therapy: Experimental only.